YLR017W
2.12.08
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SGD
MEU1
“Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression”
go molecular function : S-methyl-5-thioadenosine phosphorylase activity (IDA, IMP) (GO:0017061)
go biological process : glutamate biosynthetic process (IMP)
go biological process : methionine salvage (IDA, IMP)
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MIPS
(2.12.08 – not working)
(4.12.08)
similarity to human 5^-methylthioadenosine phosphorylase
purin nucleotide/nucleoside/nucleobase metabolism
biosynthesis of glutamate
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KEGG
Methylthioadenosine
phosphorylase (MTAP), catalyzes the initial step
in the methionine
salvage pathway; affects polyamine biosynthesis
through regulation
of ornithine decarboxylase (Spe1p) activity;
regulates ADH2 gene
expression
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Literature examined:
Subhi AL, et al. (2003) Methylthioadenosine phosphorylase regulates ornithine decarboxylase by production of downstream metabolites. J Biol Chem 278(50):49868-73
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literature_function(ylr017w, 'E.C.2.4.2.1').
2.4.2.1
purine-nucleoside
phosphorylase
purine nucleoside + phosphate = purine + α-D-ribose
1-phosphate