Prof Peter Brophy

PhD

Prof Peter Brophy

Professor

Department of Life Sciences

Contact Details

Profile

PhD on understanding how parasitic flatworms metabolise anthelmintics.  After a Medical Research Council post at Aberystwyth in parasite biochemistry gained experience in biotechnology as a research associate at the Leicester BioCentre. A Wellcome Trust Fellowship based at Nottingham University explored parasite defences against immune assault. A Senior Research Fellowship at the Leicester Pharmacy School provided opportunities in designing new approaches for target based parasite drug design. Established proteomics lead laboratories dedicated to parasite-host interactions during readership posts at the Universities of Aberystwyth and Liverpool. Returned to Aberystwyth as a Professor in Parasitology in 2007. Awarded a number of research contracts to address key problems in parasitic worm  control (vaccine, drug and diagnostic discovery).

Research

My current research interest is focused on exploiting  functional genomics to reveal how liver and rumen fluke parasites interact with their respective host environments. To date, new parasite proteins have been discovered to support drug and vaccine development and diagnostics . I am also interested in developing new molecular tools to measure anthelmintic resistance in liver fluke.

Research Groups

  • Parasitology and Helminth Control

Publications

Northcote, HM, Wititkornkul, B, Cutress, D, Allen, N, Brophy, P, Wonfor, R & Morphew, RM 2024, 'A dominance of Mu class glutathione transferases within the equine tapeworm Anoplocephala perfoliata', Parasitology, vol. 151, no. 3, pp. 282-294. 10.1017/S0031182024000015
Williams, EG, Williams, HW, Brophy, PM, Evans, SR, McCalman, H & Jones, RA 2024, 'Assessing periparturient ewe characteristics and nemabiome composition to guide targeted selective treatment for sustainable gastrointestinal nematodes control in sheep', Animal, vol. 18, no. 6, 101156. 10.1016/j.animal.2024.101156
Jones, RA, Davis, CN, Nalepa‐Grajcar, J, Woodruff, H, Williams, HW, Brophy, PM & Jones, E 2024, 'Identification of factors associated with Fasciola hepatica infection risk areas on pastures via an environmental DNA survey of Galba truncatula distribution using droplet digital and quantitative real-time PCR assays', Environmental DNA, vol. 6, no. 1, e371. 10.1002/edn3.371
McVeigh, P, McCammick, E, Robb, E, Brophy, P, Morphew, RM, Marks, NJ & Maule, AG 2023, 'Discovery of long non-coding RNAs in the liver fluke, Fasciola hepatica', PLoS Neglected Tropical Diseases, vol. 17, no. 9, e0011663. 10.1371/journal.pntd.0011663, 10.1371/journal.pntd.0011663
Williams, EG, Davis, CN, Williams, M, Jones, DL, Cutress, D, Williams, HW, Brophy, PM, Rose, MT, Stuart, RB & Jones, RA 2022, 'Associations between Gastrointestinal Nematode Infection Burden and Lying Behaviour as Measured by Accelerometers in Periparturient Ewes', Animals, vol. 12, no. 18, 2393. 10.3390/ani12182393
More publications on the Research Portal