Prof David Whitworth BA (Oxon), PhD (Warwick), SFHEA, FIBMS

Prof David Whitworth

Professor

Department of Life Sciences

Contact Details

Profile

Dave is a Professor of Biochemistry at Aberystwyth and coordinates the Biochemistry degree scheme. He studied for a BA in Biochemistry at Balliol College, Oxford (1991-1995) before completing a PhD in bacterial genetics at the University of Warwick (1999). After two postdoctoral posts and a lectureship at Warwick, Dave moved to Aberystwyth in 2008. He has been a senior fellow of the Higher Education Academy since 2016 and served a term as member of Council for the Microbiology Society. Dave's research interests include bacterial genome evolution and functional genomics (particularly of predatory myxobacteria), and the pedagogy of skills and creativity.

Research

My research focuses on the myxobacterial predator Myxococcus xanthus and how it preys upon other microbes. We are studying natural myxobacterial isolates using a variety of genomic, proteomic and phenotypic techniques to identify the genes conferring antimicrobial activity. Particular topics of interest include the predatory vesicles shed by myxobacteria, and myxobacterial genome evolution. 

Publications

Li, Z, Zhu, H, Whitworth, DE & Stevens, DC 2024, 'Biology of myxobacteria', Frontiers in Microbiology, vol. 15, 1450345. 10.3389/fmicb.2024.1450345
Swetha, RG, Arakal, BS, Rajendran, S, Sekar, K, Whitworth, DE, Ramaiah, S, James, PE, Livingstone, PG & Anbarasu, A 2024, 'MyxoPortal: A database of myxobacterial genomic features', Database: The Journal of Biological Databases and Curation, vol. 2024, baae056. 10.1093/database/baae056
Radford, EJ & Whitworth, DE 2024, The genetic basis of predation by myxobacteria. in Advances in Microbial Physiology. vol. 85, Advances in Microbial Physiology, Elsevier, pp. 1-55. 10.1016/bs.ampbs.2024.04.001
Khalid, A, Cookson, AR, Whitworth, DE, Beeton, ML, Robins, LI & Maddocks, SE 2023, 'A Synthetic Polymicrobial Community Biofilm Model Demonstrates Spatial Partitioning, Tolerance to Antimicrobial Treatment, Reduced Metabolism, and Small Colony Variants Typical of Chronic Wound Biofilms', Pathogens, vol. 12, no. 1, 118. 10.3390/pathogens12010118
Radford, E, Whitworth, D & Allison, G 2023, 'Identification of secondary metabolites containing a diketopiperazine core in extracts from myxobacterial strains with growth inhibition activity against a range of prey species', Access Microbiology, vol. 5, no. 10. 10.1099/acmi.0.000629.v4
More publications on the Research Portal