Prof Luis Mur

PhD

Prof Luis Mur

Teaching

Module Coordinator
Lecturer
Tutor
Coordinator
Moderator
Grader

Research

In my Food Security Research I am interested in developing our understanding of the genetic & biochemical events associated with plant responses to stress & in identifying sources of tolerance/resistance. This work is based on the use of model plant species, Arabidopsis & Brachypodium distachyon & also crops, wheat (Triticum aestivum), oats (Avena sativa) tomato (Solanum esculentum) & barley (Hordeum vulgare).

My interests in clinical health focus on the respiratory tract & identifying drug leads from natural products. Lung cancer (LC) is the most prevalent cancer in the world with 1.3 million deaths recorded each year. Only 15% of patients live for five or more years after initial diagnosis, primarily due to late detection. Chronic obstructive pulmonary disease (COPD) is characterised by an increase in mucus production due to hyperplasia of goblet cells, & hypertrophy of mucus glands COPD is a leading cause of death, arising from acute exacerbations (sudden worsening of symptoms) which may be triggered by infection or environmental pollutants. My research in this area is focusing on the detection of metabolite biomarkers for LC & COPD & investigating possible links with the lung microbiome.

My research in bioactive natural products focus on identifying anti-microbial metabolites against such human pathogens as MSRA & Pseudomonas aeruginosa from invasive plant species & extremophile microbial strains.

I employ cutting edge genomic & post-genomic approaches but will use classical physiological, genetic, biochemical or microbiological approaches- as appropriate. I have numerous national & international collaborations which are supported by funding from the BBSRC, the EU, NSF (USA), DEFRA, Royal Society, Welsh Assembly, & AU Research Fund.

Research Groups

  • One Health

Publications

STRESS-L. collaborators, Thomas, JL, McGee, KC, Hossain, A, Perkins, GD, Gordon, AC, Young, D, McAuley, D, Singer, M, Lall, R, Kramaric, T, Lord, JM, Whitehouse, T & Mur, LAJ 2025, 'The effects of ultra-selective beta1-antagonism on the metabolic and cytokine profile in septic shock patients receiving noradrenaline: A sub-investigation from the STRESS-L Randomised Study', Intensive Care Medicine Experimental, vol. 13, no. 1, 9, pp. 9. 10.1186/s40635-024-00708-6
Erdoğan, MŞ, Arpak, ES, Keles, CSK, Villagra, F, Işık, EÖ, Afşar, N, Yucesoy, CA, Mur, LAJ, Akanyeti, O & Saybaşılı, H 2024, 'Biochemical, biomechanical and imaging biomarkers of ischemic stroke: Time for integrative thinking', European Journal of Neuroscience, vol. 59, no. 7, pp. 1789-1818. 10.1111/ejn.16245
Padalino, G, Duggan, K, Mur, LAJ, Maillard, J-Y, Brancale, A & Hoffmann, KF 2024, 'Compounds Containing 2,3-Bis(phenylamino) Quinoxaline Exhibit Activity Against Methicillin-Resistant Staphylococcus aureus, Enterococcus faecalis, and Their Biofilms', MicrobiologyOpen, vol. 13, no. 6, e011. 10.1002/mbo3.70011
Ferreira, LC, Santana, FM, Scagliusi, SMM, Beckmann, M & Mur, LAJ 2024, 'Induced responses to the wheat pathogen: Tan Spot—( Pyrenophora tritici-repentis ) in wheat ( Triticum aestivum ) focus on changes in defence associated and sugar metabolism', Metabolomics, vol. 20, no. 1, 19. 10.1007/s11306-023-02084-w
Wang, Z, Hao, J, Shi, X, Wang, Q, Zhang, W, Li, F, Mur, LAJ, Han, Y, Hou, S, Han, J & Sun, Z 2024, 'Integrating dynamic high-throughput phenotyping and genetic analysis to monitor growth variation in foxtail millet', Plant Methods, vol. 20, no. 1, 168. 10.1186/s13007-024-01295-z, 10.1186/s13007-024-01295-z
More publications on the Research Portal